PrEP Method Comparison
Compare your PrEP options, plus condoms, and find the fit for your life.
Not sure which to choose? Answer five quick questions and we’ll score each PrEP method against your routine, then compare every option in detail below.
Taking something every single day is…
Getting to a clinic or pharmacy is…
How do you feel about injections / needles?
How important is something discreet, nothing to swallow or that others might see?
Would you rather…
Educational only, not a prescription.
Compare your options
Most of these are PrEP, prevention medicine you start before any exposure to keep HIV out. Condoms are a barrier you use during sex, and the only option here that also prevents other STIs and pregnancy. They are all about protection; the difference is how often you act and what you have to remember.
| Method | How it works | How often | Good to know |
|---|---|---|---|
| Oral PrEP (daily pill) | A daily tablet that keeps protective levels of medicine in your body. | One pill every day | Very effective when taken consistently. Discreet, widely available, and free in many programmes. Can be stopped and restarted with provider advice. |
| Dapivirine Vaginal Ring | A soft silicone ring you place inside the vagina; it slowly releases medicine right where it's needed. | Replace once a month | Woman-controlled and discreet, nothing to swallow or remember daily. A good fit if a daily pill is hard. Stays protecting you as long as it's in place. |
| CAB-LA Injectable | A long-acting injection (cabotegravir) given by a health worker into the muscle. | Two starter shots a month apart, then every 2 months | No daily pill or ring to manage. Needs a clinic visit each time, but protection lasts steadily between visits. |
| Lenacapavir Injectable (LEN) | A long-acting injection (lenacapavir) given just under the skin; it protects for months at a time. | Every 6 months, just twice a year | Begun with a short starter step, then only two clinic visits a year with nothing to manage in between. One of the newest and most effective options; availability is still expanding across the region. |
| Condoms (external or internal) | A barrier used during sex that blocks HIV. Not PrEP, but a proven method that works alongside any PrEP. | Every time you have sex | The only option here that also protects against other STIs and unplanned pregnancy. Free, widely available, and no prescription needed. Works best when used correctly and every time. |
Educational only, not a medical diagnosis.
Your health, your choice
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